Treatment of High-Risk Neuroblastoma

For information about the treatments listed below, see the Treatment Option Overview section.

Children with newly diagnosed high-risk neuroblastoma usually receive treatment in three phases: induction, consolidation, and maintenance.

Treatment during induction may include:

• combination chemotherapy
• surgery

Treatment during consolidation may include:

• two courses of high-dose combination chemotherapy followed by stem cell rescue
• radiation therapy

Treatment during maintenance may include:

• monoclonal antibody therapy (dinutuximab), granulocyte-macrophage colony-stimulating factor (GM-CSF), and isotretinoin

Treatments being studied may include:

• a clinical trial of iodine 131-MIBG therapy, targeted therapy (lorlatinib), or a vaccine to treat cancer

Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.